For Research Use Only

VeraBind Biotin™
Choose the alternative to streptavidin-based reagents with biotin interference concerns. 

If you offer in vitro diagnostic tests or create testing for clinical studies, you’re aware of the free biotin interference issue. In samples from patients who take over-the-counter biotin supplements or biotin therapy, free biotin can cause false results with tests that use anti-biotin antibodies or streptavidin-based reagents.

Veravas now has a proprietary solution. VeraBind Biotin is a novel anti-biotin monoclonal antibody (mAb) that has a high binding affinity to conjugated biotin and a very low binding affinity to free biotin — nearly a million times lower than avidin and streptavidin. Use VeraBind Biotin to replace current anti-biotin antibodies or streptavidin-based reagents, and avoid the possibility of biotin interference.

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VeraBind Biotin

Revolutionary Features

  • Similar binding affinity to biotinylated proteins as streptavidin
  • Nearly a million times lower affinity for free biotin than that of streptavidin
  • Successfully captures biotinylated targets in the presence of up to 3,500 ng/mL biotin interference
  • Without changing the test design format, developers can replace anti-biotin antibodies or streptavidin-based reagents
  • Cost-effective and accessible, with a quick protocol

VeraBind Biotin performance

Strong binding to biotinylated antibodies1

VeraBind Biotin’s affinity to biotinylated antibodies was confirmed using the ForteBio Octet RED96e System:

Highly resistant to the presence of free biotin2

In a free biotin competition study, it took 24,431 ng/mL free biotin (1.00 x 10-4 M) to suppress VeraBind Biotin’s binding by 50% as compared to only 0.028 ng/mL free biotin (1.15 x 10-10 M) with Streptavidin. 

Since the FDA has requested that assay manufacturers test for biotin interference up to 3,000 ng/mL3, developers can have a high level of confidence whenusing VeraBind Biotin in their tests.

Contact us and we’ll work with you to redesign your tests with VeraBind Biotin.

Veravas is transforming laboratory medicine with testing technology that strengthens quality of care for clinicians and patients. Our passionate and dedicated team can help address biotin-interference in your tests and assays. Get in touch with us to discuss how we can help you.

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See the VeraBind Biotin flyer for more details.

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Order VeraBind Biotin mAb to evaluate in your tests.

Get VeraBind Biotin antibodies and begin redesigning your tests.

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References
1. Veravas, Inc. Data on file.
2. Veravas, Inc. Data on file.
3. FDA Draft Guidance:Testing for Biotin Interference in In Vitro Diagnostic Devices. June 2019.https://www.federalregister.gov/documents/2019/06/14/2019-12564/testing-for-biotin-interference-in-in-vitro-diagnostic-devices-draft-guidance-for-industry